Beyond the Dilemmas: Design of PLA-PEG Assemblies Based on pH-Reversible Boronic Ester for the Synchronous PEG De-Shielding and Ligand Presentation to Hepatocytes
نویسندگان
چکیده
A new polymeric construct is proposed as a starting material for liver-targeted delivery system in the present communication. The has been designed to be sensitive pH variations and potentially loaded with hydrophobic antitumoral agents. It based on one of most used copolymers field nanomedicine: PEG-PLA. latter, usually obtained by polymerization lactic acid hydroxyl-terminated polyether, assembled pH-reversible condensation between phenylboronic acid-ended methoxy PEG 2000 (MeO-PEG2000-PBA) galactose-capped PLA 1–10 kDa (PLA-Gal). Our approach strategic assumption that would allow ligand presentation strategy which Gal both structural element stimulus-responsive de-shielding targeting moiety. Indeed, vicinal diol able form reversible boronate ester B(OH) 2 residue, cleavable at acidic tumor microenvironment, it also recognized asialoglycoprotein receptor, hyper-expressed membrane hepatocytes. functionalization two blocks presented here, they are characterized using NMR, FTIR, GPC. analytical evaluation ability boronated condense sensible way completes study.
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ژورنال
عنوان ژورنال: Applied sciences
سال: 2022
ISSN: ['2076-3417']
DOI: https://doi.org/10.3390/app12094225